|本期目录/Table of Contents|

[1]陈超,单其艳,杨铭,等. 蚕蛹壳聚糖复合止血材料的制备及凝血性能初探[J].丝绸,2011,48(06):000012-16.
 CHEN Chao,SHAN Qi-yan,YANG Ming,et al. Preparation and clotting property of a silkworm pupa-derived chitosan composite haemostatic material[J].Journal of Silk,2011,48(06):000012-16.
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 蚕蛹壳聚糖复合止血材料的制备及凝血性能初探(PDF)
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《丝绸》[ISSN:1001-7003/CN:33-1122/TS]

卷:
48
期数:
2011年06期
页码:
000012-16
栏目:
研究与技术
出版日期:
2011-06-30

文章信息/Info

Title:
 Preparation and clotting property of a silkworm pupa-derived chitosan composite haemostatic material
文章编号:
1001-7003(2011 )06-0012-05
作者:
 陈超单其艳杨铭蓝广芊吴大洋
 西南大学 纺织服装学院,重庆 400716
Author(s):
 CHEN Chao SHAN Qi-yan YANG Ming LAN Guang-qian WU Da-yang
 College of Textile & Garment, Southwest University, Chongqing 400716, China
关键词:
 蚕蛹壳聚糖明胶海绵凝血指数止血材料
Keywords:
 Silkworm pupa Chitosan Gelatin Sponge Blood clotting index Haemostatic material
分类号:
TS149
doi:
-
文献标志码:
A
摘要:
    探讨以蚕蛹壳聚糖(CS)和明胶(GEL)为主要原料制备复合止血材料的工艺及凝血效果。首先从蚕蛹中提取出壳聚糖,与明胶共混溶解后添加助剂,通过冷冻真空干燥法制备海绵状复合止血材料,然后采用凝血指数BCI进行体外凝血测试,研究其制备工艺参数对凝血效果的影响。实验表明,最佳工艺参数为:-40 ℃下预冻1?h,共混溶液质量浓度为30 g/L,mCS∶mGEL=5∶5。0.01?%的戊二醛、0.5 %的氯化钙能有效提高样品的凝血效果。凝血指数BCI相对于医用纱布和明胶止血海绵分别降低了63.52 %和34.85 %,凝血效果得到显著提高。
Abstract:
 This paper discussed the technology and clotting effect of composite haemostatic material, which wasmade from gelatin and chitosan. The chitosan was derived from silkworm pupa. Mixed with gelatin and some additives, the chitosan became sponge by means of freeze drying. Then, extracorporeal blood coagulation test was conducted using clotting index BCI and the effect of processing technology on clotting effect was studied. Experiment results showed that the optimal technological parameters were determined as follows: pre frozen 1h at -40 ℃, blending solution mass concentration of 30 g/L, mCS∶mGE=5∶5, and the haemostatic property can be improved by adding 0.01 % calcium chloride and 0.5 % glutaraldehyde. Its haemostatic property was better than hospital gauze and gelatin sponge with the BCI reduced by 63.52% and 34.85%.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2011 -01-18;修回日期:2011 -03-08
基金项目:重庆市科技攻关计划项目(CSTC,2008AB1005)
作者简介:陈超(1987- ),男,硕士研究生,研究方向为新型资源纤维的开发与应用。通讯作者:吴大洋,教授,博导,wdy1484@swu.edu.cn
更新日期/Last Update: 2012-03-14